In light of the UKHSA principles paper, a risk stratified clinical approach has been developed to ensure that confirmed cases of monkeypox receive appropriate care, while also managing transmission risk. This approach is being further modified to take account of the derogation of the current specific monkeypox clade (clade IIb with lineage B.1) AND (as of December 2022) cases in clade II non-B.1 lineage (i.e those associated with travel to West Africa) as a High Consequence Infectious Disease (HCID).