Lipid Management – Rapid Uptake Product

What is it?

The Lipid Management rapid uptake product (RUP) is a NICE-endorsed clinical pathway to better manage and treat high cholesterol levels. The aim is to improve patient outcomes by reducing the incidence of cardiovascular events including heart attacks or strokes. This RUP has a focus on secondary prevention.

There are three classes of medicines in the clinical pathway: high-intensity statins (HISTs); Ezetimibe; and PCSK9 inhibitors. All three lower low-density lipoprotein (LDL) cholesterol.

HISTs help reduce LDL cholesterol.

Ezetimibe can be used either as an adjunct to HISTs or as monotherapy (the use of a single drug to treat a disease or condition) if a patient is intolerant to statins. They may also be used in addition to a PCSK9 inhibitor.

Two medicines, Alirocumab and Evolocumab, belong to a class of medicines known as PCSK9 inhibitors. A PCSK9 inhibitor can be used together with statins in patients who require further lipid lowering or independently in those who are unable to take or tolerate a statin.

Where CCGs adopt a ‘Blueteq prior approval’ form for selected high cost medicines, the AAC has designed a standardised form to secure approval of PCSK9 inhibitors. The form incorporates the information required in accordance with NICE guidance TA393 and TA394.

What are the benefits?

  • Reduced risk of admissions and re-admissions associated with cardiovascular disease.
  • HISTs and Ezetimibe are both generic medicines available in primary and secondary care.
  • In clinical trials PCSK9 inhibitors have been shown to reduce LDL by approximately 55-60%
  • Large scale outcomes trials have also shown PCSK9 inhibitors to lower the risk of heart attack and stroke.
  • PCSK9 inhibitors provide an additional treatment option to statins and ezetimibe in high-risk patients who previously remained at risk despite receiving the maximum dose of those medicines that the individual could tolerate.
  • PCSK9 inhibitors can be self-administered by patients with free homecare service available.

Further information

The AAC has developed a Lipid Management Algorithm for Primary and Secondary Prevention of Cardiovascular Disease and a companion document dealing with statin intolerance. These guidance documents simplify and encourage adherence to national guidance for optimal management of patients with hypercholesterolaemia and have been endorsed by NICE:

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