This webpage provides advice and recommendations to healthcare providers on how to manage patients with mpox caused by any clade of mpox virus, following the removal of high consequence infectious disease (HCID) status for all mpox clades.

Accessible content.

Published 7 July 2025.

** This document has been withdrawn, please refer to the latest guidance **

Letter and guidance.

Published 1 February 2023.

** This document has been withdrawn, please refer to the latest guidance **

In response to the monkepox outbreak, in line with the UK Health Security Agency principles paper, a risk stratified clinical approach has been developed to ensure that confirmed cases receive appropriate care, while also managing transmission risk.

Updated 22 September 2022.

** This document has been withdrawn, please refer to the latest guidance **

This letter explains that the public health agencies of the four nations of the UK have agreed that, as from 5 July 2022, the current specific outbreak clade of monkeypox in the UK will no longer be designated as a high consequence infectious disease.

Published 6 July 2022.

** This document has been withdrawn, please refer to the latest guidance **

This letter outlines the NHS response to the ongoing monkeypox outbreak.

Published 1 June 2022.

** This document has been withdrawn, please refer to the latest guidance **

This guidance sets out measures for the operational delivery of monkeypox vaccinations in line with UK Health Security Agency (UKHSA) guidance.

Published 23 June 2022.

** This document has been withdrawn, please refer to the latest guidance **

This document sets out the safe care of positive monkeypox cases who are able to isolate at home.

Published 21 June 2022.

** This document has been withdrawn, please refer to the latest guidance **

Published 21 June 2022.