In circumstances when NHS England needs to implement a commissioning policy quickly, a policy statement or urgent policy statement will be developed. These policy statements have been through the standard development process for all policies, including evidence review, impact analysis and decision by the Clinical Priorities Advisory Group (CPAG), however they have not been subject to public consultation. Once the policy statement is published, a full clinical commissioning policy may be developed.

Routinely commissioned:

• Abatacept for treatment of severe treatment-resistant morphoea (localised scleroderma)
• Active middle ear implants
• Alemtuzumab for treating relapsing-remitting multiple sclerosis – third cycle (all ages)
• Antivirals for adults with recent onset (acute) hepatitis C
• Biologic therapies for the treatment of juvenile idiopathic arthritis
• Docetaxel in combination with androgen deprivation therapy for the treatment of hormone naïve metastatic prostate cancer
• Dolutegravir/lamivudine for the treatment of Human Immunodeficiency Virus (HIV-1) infected adults and adolescents over 12 years of age
• Everolimus (Votubia®) for treatment of angiomyolipomas associated with tuberous sclerosis
• Flow diverting devices for intracranial aneurysms
• Ivacaftor, tezacaftor/ivacaftor, lumacaftor/ivacaftor and elexacaftor/tezacaftor/ivacaftor for cystic fibrosis
• Pectus surgery for pectus excavatum deformities resulting in very severe physiological symptoms (all ages)
• Pembrolizumab for drug-resistant gestational trophoblastic neoplasia
• Parenteral nutrition for the treatment of adults and children with Type 2 and Type 3 intestinal failure requiring home parenteral support
• Pharmacogenomic testing for DPYD polymorphisms with fluoropyrimidine therapies
• Positron emission tomography – Computed tomography guidelines (all ages)
• Prenatal surgery for open spina bifida
• Plerixafor for stem cell mobilisation in adults and children
• Retreatment of Chronic Hepatitis C infection in adults with advanced or decompensated cirrhosis
• Rituximab biosimilar for the treatment of myasthenia gravis (adults)
• Rituximab for the treatment of systemic lupus erythematosus in adults
• Stereotactic ablative body radiotherapy for patients with locally advanced, inoperable, non-metastatic pancreatic carcinoma
• Stereotactic radiosurgery / radiotherapy for ocular melanoma and pituitary adenoma
• Stereotactic Radiosurgery and Stereotactic Radiotherapy for Primary Non-Germ Cell Pineal Tumours (All Ages)
• Stereotactic Radiosurgery and Stereotactic Radiotherapy for Intracranial Ependymoma (Children)
• Subcutaneous copper histidinate injections for presymptomatic neonates with classical Menkes disease
• Surgical treatment of complex primary cardiac tumours in children
• Teriparatide for osteoporosis in men (adults)
• Treatment for defined patients with MDR-TB and XDR-TB including bedaquiline and delamanid
• Treatment of chronic hepatitis C in patients with cirrhosis
• Uridine triacetate for the treatment of patients exhibiting early onset severe toxicities following 5-fluorouracil or capecitabine administration (all ages)
• Vestronidase alfa for Mucopolysaccharidosis Type VII (MPS, Sly syndrome) (infantile)

Not for routine commissioning:

• Allogenic Mesenchymal Stromal Cell Infusion Therapy for Children with Severe Generalised Recessive Dystrophic Epidermolysis Bullosa
• Arsenic trioxide for the treatment of high risk acute promyelocytic leukaemia
• Cerebellar stimulator implants
• Convection enhanced delivery for diffuse intrinsic glioma
• Deep brain stimulation for indications except movement disorders
• Eculizumab in the prevention of recurrence of C3 glomerulopathy post kidney transplant
• Natalizumab-induced progressive multifocal leukoencephalopathy in relation to immune reconstitution inflammatory syndrome in multiple sclerosis
• Osseointegration for transfemoral amputation (adults)
• Pazopanib for inoperable and metastatic malignant granular cell tumour (all ages)
• Proton Beam Therapy for Adult Lymphoma
• Proton Beam Therapy for Head and Neck Cancer in Adults
• Proton Beam Therapy for Hepatocellular Carcinoma
• Proton Beam Therapy for Lung Cancer (Adults)
• Proton Beam Therapy for Oesophageal Cancer in Adults
• Rituximab for the treatment of refractory focal segmental glomerulosclerosis in the native kidney in adults
• Selective Internal Radiotherapy (SIRT) in the treatment of secondary liver cancers (all ages)
• Sphenopalatine Ganglion Stimulation for Refractory, Chronic Cluster Headache (adults)
• Surgical treatment for women who have undergone female genital mutilation
• Use of Adalimumab for Osteomyelitis