Policies: Routinely commissioned
A commissioning policy is a document that defines access to a service for a particular group of patients. A NICE Technology Appraisal Guideline on the same topic will replace, or be incorporated into, a commissioning policy as appropriate. These are important documents that are developed to ensure consistency in access to treatments nationwide.
- Abatacept for treatment of severe treatment-resistant morphoea (localised scleroderma)
- Abatacept for refractory idiopathic inflammatory myopathies (adults and children aged 2 years and over)
- Addition of rituximab to first-line standard chemotherapy for CD20 positive B-cell precursor acute lymphoblastic leukaemia (adults)
- Allogeneic haematopoietic stem cell transplantation (Allo-HSCT) for adult transfusion dependent thalassaemia
- Allogeneic haematopoietic stem cell transplantation for adults with sickle cell disease
- Allogeneic haematopoietic stem cell transplant for patients with X-linked cerebral adrenoleukodystrophy (adults)
- Allogeneic haematopoietic stem cell transplant for primary immunodeficiencies (all ages)
- Anakinra to treat periodic fevers and autoinflammatory diseases (all ages)
- Anakinra for haemophagocytic lymphohistiocytosis for adults and children in all ages
- Auditory brainstem implant with congential abnomalities of the auditory nerves of cochleae
- Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension (all ages)
- Baricitinib for use in monogenic interferonopathies (adults and children 2 years and over)
- Bedaquiline (B), pretomanid (Pa), linezolid (L) +/- moxifloxacin (M) (BPaLM/BPaL) for patients aged ≥14 years with suspected, functional or confirmed rifampicin resistant (RR) tuberculosis (TB), multidrug-resistant (MDR) TB or pre-extensively drug resistant (pre-XDR) TB
- Bendamustine with rituximab for first line treatment of advanced indolent non-Hodgkin’s lymphoma (all ages)
- Bendamustine with rituximab for first line treatment of mantle cell lymphoma (all ages)
- Bendamustine with rituximab for relapsed and refractory mantle cell lymphoma (all ages)
- Bictegravir-emtricitabine-tenofovir alafenamide for the treatment of HIV-1 in adults
- Bone anchored hearing aids
- Bone conducting hearing implants for hearing loss (all ages)
- Bone morphogenic protein-2 for spinal fusion
- Brachytherapy dose escalation with external beam radiotherapy for intermediate- and high-risk localised prostate cancer
- Canakinumab for treating periodic fever syndromes: TRAPS, HIDS/MKD and FMF (ages 2 years and older)
- Cervical disc replacement for cervical radiculomyelopathy
- Cholic acid and chenodeoxycholic acid for treating inborn errors of bile acid synthesis (all ages)
- Cinacalcet for complex primary hyperparathyroidism
- Clinical commissioning policy: Catheter ablation for paroxysmal and persistent atrial fibrillation (adults)
- Commissioning medicines for children in specialised services
- Complex endovascular stent grafts in abdominal aortic aneurysm
- Cytoreductive surgery for patients with peritoneal carcinomatosis
- Dabrafenib and trametinib in the treatment of patients with BRAF-mutated anaplastic thyroid cancer
- Deep brain stimulation in movement disorders
- Defibrotide for severe veno-occlusive disease following stem cell transplant
- Dexrazoxane for preventing cardiotoxicity in children and young people (under 25 years) receiving high-dose anthracyclines or related drugs for the treatment of cancer
- Dialysis away from base
- Disease modifying therapies for patients with multiple sclerosis
- Dolutegravir for treatment of HIV-1 infection (all ages)
- Dolutegravir-rilpivirine for treating HIV-1 in adults
- Doravirine for the treatment of HIV-1 in adults
- Eculizumab in the treatment of recurrence of C3 glomerulopathy post-kidney transplant (all ages)
- Elvitegravir/cobicistat/emtricitabine/tenofovir for treatment of HIV in adults
- Emicizumab as prophylaxis in people with congenital haemophilia A with factor VIII inhibitors
- Emicizumab as prophylaxis in people with severe congenital haemophilia A without factor VIII inhibitors (all ages)
- Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above)
- Everolimus for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
- External beam radiotherapy for patients presenting with hormone sensitive, low volume metastatic prostate cancer at the time of diagnosis
- Extracorporeal membrane oxygenation (ECMO) as abridge to lung transplant (all ages)
- Fostemsavir for multi-drug resistant HIV-1 infection (adult)
- Fresh osteochondral allograft for osteochondral lesions of the knee in adults and post-pubescent children
- Gemcitabine and capecitabine following surgery for pancreatic cancer (all ages)
- Genetic testing for BRCA1 and BRCA2 mutations
- Glucarpidase for the urgent treatment of methotrexate-induced renal dysfunction
- Haematopoietic stem cell transplantation (All Ages)
- Haematopoietic stem cell transplantation for lymphoplasmacytic lymphoma (adults)
- Hand and upper limb reconstruction using vascularised composite allotransplantation
- Human coagulation factor X for hereditary factor X deficiency (all ages)
- Human normal immunoglobulin for treatment of scleromyxedema (adults)
- Hyperbaric oxygen therapy for decompression illness/gas embolism
- Hypofractionated external beam radiotherapy for the treatment of localised prostate cancer
- Immediate antiretroviral therapy for treatment of HIV-1 in adults and adolescents
- Immune tolerance induction for haemophilia A (all ages)
- Infliximab for refractory or progressive neurosarcoidosis (adults and post-pubescent children)
- Infliximab for refractory sarcoidosis (excluding neurosarcoidosis)
- Inhaled therapy for adults and children with cystic fibrosis
- Intrathecal Baclofen
- Intrathecal pumps for treatment of severe cancer pain
- Keratoprosthesis for corneal blindness (all ages)
- Left atrial appendage occlusion for patients with atrial fibrillation and relative or absolute contraindications to anticoagulation (adults)
- Levodopa-carbidopa intestinal gel (LCIG) and levodopa-carbidopa-entacapone intestinal gel (LECIG) for Parkinson’s disease (adults)
- Levofloxacin nebuliser solution for chronic Pseudomonas lung infection in cystic fibrosis (adults)
- Lomitapide for treating homozygous familial hypercholesterolaemia (adults)
- Lung volume reduction by surgery or endobronchial valve for severe emphysema in adults
- Management of fetal anaemia secondary to red cell alloimmunisation (fetal transfusion)
- Management of twin to twin syndrome
- Maternal intravenous immunoglobulin for the prevention of allo-immune fetal and neonatal haemochromatosis
- Mecasermin for treatment of growth failure
- Mechanical thrombectomy for acute ischaemic stroke (all ages)
- Mercaptamine hydrochloride viscous eyedrops for corneal cystine deposits in people aged 2 years and over
- Metreleptin for congenital leptin deficiency (all ages)
- Microprocessor controlled prosthetic knees
- MR-guided laser interstitial thermal therapy for treatment of epileptogenic zones in children and adults with refractory focal epilepsy
- Multi-grip prosthetic hand (all ages)
- Nebulised liposomal amikacin for the treatment of non-tuberculous mycobacterial pulmonary disease caused by mycobacterium avium complex refractory to current treatment options (adults and post pubescent children)
- Obesity surgery for children with severe complex obesity
- Obinutuzumab elective therapy to prevent immune Thrombotic Thrombocytopenic Purpura (TTP) relapse in patients who are refractory or intolerant to rituximab (adults)
- Occipital nerve stimulation for adults with intractable chronic migraines and medically refractory chronic cluster headaches
- Palliative radiotherapy for bone pain
- Pasireotide: an injectable medical therapy for the treatment of Cushing’s disease
- Pegvisomant for acromegaly as a third-line treatment (adults)
- Penile prostheses for end stage erectile dysfunction
- Percutaneous mitral valve leaflet repair for primary degenerative mitral regurgitation in adults
- Percutaneous patent foraman ovale closure for the prevention of recurrent cerebral embolic stroke in adults (around the age 60 years and under)
- Phrenic nerve pacing following spinal cord injury
- Plasma-derived C1-esterase inhibitor for prophylactic treatment of hereditary angioesema types I and II
- Plerixafor for stem cell mobilisation in adults and children
- Pre-implantation genetic diagnosis
- Prescribing of gender affirming hormones (masculinising or feminising hormones) as part of the children and young people’s gender service
- Proton beam therapy for children, teenagers and young adults in the treatment of malignant and non-malignant tumours
- Proton beam therapy for craniospinal irradiation in adults
- Proton beam radiotherapy (high energy) for skull base tumour treatment – NHS overseas programme (Adult)
- Radiotherapy after primary surgery for breast cancer
- Ranibizumab in retinopathy of prematurity
- Reimbursement of expenses for living donors
- Reimbursement for the use of generic drugs for pre exposure prophylaxis (PrEP) for the prevention of HIV
- Retreatment of chronic hepatitis C infection in adults with advanced or decompensated cirrhosis
- Riociguat for pulmonary arterial hypertension
- Rituximab and eculizumab for the prevention and management of delayed haemolytic transfusion reactions and hyperhaemolysis in patients with haemoglobinopathies
- Rituximab and anti-neutrophic cytoplasmic antibody associated vasculitis
- Rituximab as a second line agent for the eradication of inhibitors in patients with acquired haemophilia
- Rituximab for cytopaenia complicating primary immunodeficiency
- Rituximab for idiopathic membranous nephropathy (adults)
- Rituximab for immunobullous disease
- Rituximab for immunoglobulin G4-related disease (IgG4-RD)
- Rituximab for refractory Systemic Lupus Erythematosus (SLE) in adults and post-pubescent children
- Rituximab for second line treatment for anti-NMDAR autoimmune encephalitis
- Rituximab for the treatment of dermatomyositis and polymyositis (adults)
- Rituximab for the treatment of IgM paraproteinaemic demyelinating peripheral neuropathy in adults
- Rituximab for the treatment of relapsing steroid sensitive nephrotic syndrome
- Rituximab for the treatment of steroid resistant nephrotic syndrome in paediatric patients
- Rituximab for the treatment in acute Thrombotic Thrombocytopenic Purpura (TTP) and elective therapy to prevent TTP relapse
- Rituximab therapy for the treatment of nodal/paranodal antibody positive inflammatory/autoimmune neuropathy in adults and postpubescent children
- Robotic assisted surgery for kidney cancer
- Robotic assisted surgical procedures for prostate cancer
- Sacral nerve stimulation for faecal incontinence (Adult)
- Sacral nerve stimulation for overactive bladder
- Sapropterin for phenylketonuria – use in pregnancy
- Second allogeneic haematopoietic stem cell transplant for relapsed disease (all ages)
- Selective dorsal rhizotomy for the treatment of spasticity in cerebral palsy (children aged 3-9 years)
- Selective internal radiation therapy for chemotherapy refractory intolerant metastatic colorectal cancer (adults)
- Selexipag for treating pulmonary arterial hypertension (adults)
- Serum eye drops for the treatment of severe ocular surface disease (all ages)
- Sildenafil and bosentan for the treatment of digital ulceration in systemic sclerosis
- Siltuximab for idiopathic multicentric Castleman disease (adults)
- Sodium oxybate for symptom control of narcolpesy with cataplexy (children and adolescents aged 7 until 19 years)
- Sorafenib maintenance for adults with FLT3-internal tandem duplication (FLT3-ITD) acute myeloid leukaemia (AML) undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT)
- Stereotactic ablative body radiotherapy for non-small-cell lung cancer (adults)
- Stereotactic ablative radiotherapy (SABR) for Hepatocellular Carcinoma (adults)
- Stereotactic ablative radiotherapy (SABR) for patients with metachronous extracranial oligometastatic cancer (all ages)
- Stereotactic ablative radiotherapy (SABR) for patients with previously irradiated, locally recurrent primary pelvic tumours (all ages)
- Stereotactic radiosurgery/radiotherapy for cavernous venous malformations (cavernomas)
- Stereotactic radiosurgery/radiotherapy for cerebral metastases
- Stereotactic radiosurgery/radiotherapy for epedymoma, haemangioblastoma, pilocytic astrocytoma and trigeminal schwannoma
- Stereotactic/radiosurgery radiotherapy for glomus tumours (skull base paragangliomas, glomus jugulare tumours)
- Stereotactic radiosurgery/radiotherapy for meningioma
- Stereotactic radiosurgery/radiotherapy for the treatment of pituitary adenomas
- Stereotactic radiosurgery/radiotherapy for vestibular schwannoma and other cranial nerve neuromas
- Stereotactic radiosurgery for cerebral arteriovenous malformations
- Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) to the surgical cavity following resection of cerebral metastases (All ages)
- Stereotactic radiosurgery for trigeminal neuralgia
- Subcutaneous copper histidinate injections for presymptomatic neonates with classical Menkes disease
- Surgical sperm retrieval for male infertility
- Susoctocog alfa for treating bleeding episodes in people with acquired haemophilia A (all ages)
- Targeted therapies for pulmonary hypertension functional class II
- Targeted therapies for use in pulmonary hypertension in adults
- Temozolomide as adjuvant treatment for people with newly diagnosed anaplastic astrocytoma without 1p/19q codeletion following surgery and radiotherapy (adults)
- Tenofovir Alafenamide for treatment of HIV 1 in adults and adolescents
- Tocilizumab for Takayasu arteritis
- Tocilizumab for the treatment of adult-onset Still’s disease refractory to second-line therapy (adults)
- Tolvaptan for hyponatraemia secondary to the syndrome of inappropriate antidiuretic hormona in patients requiring cancer chemotherapy
- Total pancreatectomy with islet auto transplant for chronic pancreatitis (adults)
- Trametinib in recurrent or progressive low grade serous ovarian cancer (adults)
- Transcatheter aortic value implantation
- Transcranial magnetic resonance guided focused ultrasound thalamotomy for treatment of medication-refractory essential tremor (effective from 1 April 2021)
- Treatment as prevention in HIV infected adults
- Treatment of acute attacks in hereditary angiodema (adult)
- Treatment of chronic Hepatitis C in patients with cirrhosis
- Treatment of iron overload for transfused and non transfused patients with chronic inherited anaemias
- Treatment of iron overload for transfused and non-transfused patients with chronic inherited anaemias (all ages)
- Treatments for graft versus host disease following haematopoietic stem cell transplantation
- Trientine for Wilson disease (all ages)
- Urethroplasty for benign urethral strictures in adult men
- Vagal nerve stimulation for epilepsy
- Vismodegib for adults with either Gorlin syndrome or non-Gorlin syndrome related multiple basal cell carcinomas. (Adults)
- Vonicog alfa for the treatment and prevention of bleeding in adults with von Willebrand disease